Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells.

@article{Johnston2004PeripheralBT,
  title={Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells.},
  author={A Johnston and Johann Eli Gudj{\'o}nsson and Hekla Sigmundsd{\'o}ttir and Thorvardur Jon Love and Helgi Valdimarsson},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={138 1},
  pages={83-93}
}
The association of psoriasis with Streptococcus pyogenes throat infections suggests a potential antigenic target for the T cells that are known to infiltrate psoriatic skin. Streptococcal M protein share an extensive sequence homology with the human epidermal keratins. Keratin 17 (K17), while being mostly absent from uninvolved skin, is up-regulated in psoriatic lesions. Consequentially, M-protein-primed T cells may recognize up-regulated keratin epitopes via molecular mimicry. Using in vitro… CONTINUE READING

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