Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load.

@article{Molling2005PeripheralBI,
  title={Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load.},
  author={Johan W. Molling and Wendy K{\"o}lgen and Hans J. J. van der Vliet and Martijn F. Boomsma and Hinke M. Kruizenga and C H Smorenburg and Barbara Molenkamp and Johannes A. Langendijk and C. Rene ¤ Leemans and Brigitta Mary E von Blomberg and Rik J. Scheper and Alfons J. M. van den Eertwegh},
  journal={International journal of cancer},
  year={2005},
  volume={116 1},
  pages={87-93}
}
Natural killer T (NKT) cells are CD1d-restricted lymphoid cells and are characterized by an invariant T-cell receptor, which in humans consists of a Valpha24 chain paired with a Vbeta11 chain. These cells are known for their rapid production of large amounts of cytokines (e.g., IFN-gamma and IL-4), thereby modulating other cells of the immune system such as T cells, NK cells and dendritic cells. NKT cells have been reported to play important regulatory roles in many immune responses, including… CONTINUE READING