Peripheral benzodiazepine receptors: molecular pharmacology to possible physiological significance in stress-induced hypertension.

@article{Drugan1996PeripheralBR,
  title={Peripheral benzodiazepine receptors: molecular pharmacology to possible physiological significance in stress-induced hypertension.},
  author={Robert C. Drugan},
  journal={Clinical neuropharmacology},
  year={1996},
  volume={19 6},
  pages={475-96}
}
Simultaneous to the discovery of binding sites for benzodiazepines in the central nervous system (CNS) was the observation that [3H]diazepam also bound to sites in peripheral tissues, including liver, heart, lung, adrenal, and kidney. These "peripheral" benzodiazepine receptors (PBR) have been well characterized, but their physiological significance remains elusive. Researchers have discovered candidates that may serve as endogenous ligands for the PBR. The PBR is both tonically and phasically… CONTINUE READING