Peripheral arterial disease in randomized trial of estrogen with progestin in women with coronary heart disease: the Heart and Estrogen/Progestin Replacement Study.

@article{Hsia2000PeripheralAD,
  title={Peripheral arterial disease in randomized trial of estrogen with progestin in women with coronary heart disease: the Heart and Estrogen/Progestin Replacement Study.},
  author={Judith A Hsia and Joel A Simon and Feng Lin and William B. Applegate and Molly T. Vogt and Donald B. Hunninghake and Mitchell Carr},
  journal={Circulation},
  year={2000},
  volume={102 18},
  pages={2228-32}
}
BACKGROUND Postmenopausal estrogen use has been associated with reduced carotid atherosclerosis in observational studies, but this relationship has not been confirmed in a clinical trial. The impact of estrogen on atherosclerotic disease in other peripheral arteries is unknown. METHODS AND RESULTS Postmenopausal women with coronary heart disease (CHD) and an intact uterus (n=2763) were randomly assigned to conjugated equine estrogens (0.625 mg) combined with medroxyprogesterone acetate (2.5… CONTINUE READING

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