Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis.

@article{Khandanpour2009PeripheralAD,
  title={Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis.},
  author={Nader Khandanpour and G. Willis and Felicity J. Meyer and Matthew P. Armon and Yoon K Loke and Anthony J A Wright and Paul M Finglas and B A Jennings},
  journal={Journal of vascular surgery},
  year={2009},
  volume={49 3},
  pages={
          711-8
        }
}
OBJECTIVE Hyperhomocysteinaemia is associated with peripheral arterial disease (PAD). There are inter-individual variations in the metabolism of homocysteine because of genetic polymorphisms. This study analyzed the role of one polymorphism that is associated with raised homocysteine, as a risk factor for PAD. METHODS This study considered the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with the incidence of PAD by performing a case-control study and a cross… CONTINUE READING

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