Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation.

@article{Koppert1999PeripheralAE,
  title={Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation.},
  author={Wolfgang Koppert and Rudolf Likar and Gerd 7 Geisslinger and Susanne Zeck and Martin Schmelz and Ruth Sittl},
  journal={Anesthesia and analgesia},
  year={1999},
  volume={88 1},
  pages={117-22}
}
UNLABELLED The objective of this study was to evaluate direct peripheral analgesic effects of morphine using a peripheral model of hyperalgesia and the technique of IV regional anesthesia (IVRA), thus allowing the differentiation between central and peripheral mechanisms of action. Two spots on the ventral sides of both forearms in 12 volunteers were irradiated with ultraviolet (UV)-B to induce thermal and mechanical hyperalgesia. One day after the induction of the inflammatory reaction, 40 mL… CONTINUE READING

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