Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain.

@article{Burian2003PeripheralAC,
  title={Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain.},
  author={Maria Burian and Irmgard Tegeder and Maic Seegel and Gerd 7 Geisslinger},
  journal={Clinical pharmacology and therapeutics},
  year={2003},
  volume={74 2},
  pages={113-20}
}
AIM Experimental evidence suggests that the antihyperalgesic effect of nonsteroidal anti-inflammatory drugs may include both peripheral (inflammatory site) and central sites of action. The aim of this study was to assess peripheral and central antihyperalgesic effects of diclofenac in a human experimental pain model. METHODS This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via… CONTINUE READING