Peripheral analgesic and antiinflammatory effects of opioids

@article{Stein2001PeripheralAA,
  title={Peripheral analgesic and antiinflammatory effects of opioids},
  author={Christoph Stein and Halina Machelska and Martin Schaefer},
  journal={Zeitschrift f{\"u}r Rheumatologie},
  year={2001},
  volume={60},
  pages={416-424}
}
Traditionally, opioids were considered the prototype of centrally acting analgesics. In the past decade a substantial literature has emerged demonstrating that opioids can produce potent and clinically measurable analgesia by activation of opioid receptors on peripheral terminals of primary sensory neurons. In addition, endogenous ligands of these peripheral receptors were discovered in immune cells. Major recent findings in peripheral opioid analgesia include the relative lack of tolerance… CONTINUE READING
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