Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.

@article{Durate1990PeripheralAA,
  title={Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.},
  author={I D Durate and Berenice B. Lorenzetti and S{\'e}rgio H. Ferreira},
  journal={European journal of pharmacology},
  year={1990},
  volume={186 2-3},
  pages={
          289-93
        }
}
Ketamine Activates the l-Arginine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway to Induce Peripheral Antinociception in Rats
TLDR
The results suggest that ketamine stimulates the l-arginine/NO/cyclic GMP pathway via neuronal NO synthase to induce peripheral antinociceptive effects.
The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats.
  • F. A. B. Maegawa, C. R. Tonussi
  • Biology, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2003
TLDR
The view that fentanyl reverses prostaglandin E2-induced hyperalgesia is supported, probably by activating an opioid receptor at the periphery, and furthermore the L-arginine/nitric oxide/cyclic-GMP pathway may mediate this peripheral effect of fentanyl.
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive effect of nimesulide.
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TLDR
The results support the proposal that l‐arginine is the physiological precursor for the basal and stimulated generation of nitric oxide for endothelium‐dependent relaxation.
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