Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

@inproceedings{Godai2014PeripheralAO,
  title={Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway},
  author={Kohei Godai and Maiko Hasegawa-Moriyama and Tae Kurimoto and Takayuki Saito and Tomotsugu Yamada and Takahiro Sato and Masayasu Kojima and Yuichi Kanmura},
  booktitle={Molecular pain},
  year={2014}
}
BACKGROUND Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chronic inflammation is regulated by macrophage polarity, often referred to as proinflammatory (M1) or anti-inflammatory (M2) macrophages. Although opioids such as morphine are known to alter the inflammatory milieu of incisional wounds through interactions with immunocytes, the… CONTINUE READING
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