Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents.

@article{PauchaPoniewiera2008PeripheralAO,
  title={Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents.},
  author={Agnieszka Pałucha-Poniewiera and Aleksandra Kłodzińska and Katarzyna Stachowicz and Krzysztof Tokarski and Grzegorz Hess and Stephan Schann and M{\'e}lanie Frauli and Pascal Neuville and Andrzej Pilc},
  journal={Neuropharmacology},
  year={2008},
  volume={55 4},
  pages={517-24}
}
Several lines of evidence implicate dysfunction of glutamatergic neurotransmission in the pathophysiology of schizophrenia. Previous behavioral studies have indicated that metabotropic glutamate (mGlu) receptors may be useful targets for the treatment of psychosis. It has been shown that agonists and positive allosteric modulators of group II mGlu receptors produce potential antipsychotic effects in behavioral models of schizophrenia in rodents. Group III mGlu receptors seem to be also… CONTINUE READING