Peripheral administration of brain-derived neurotrophic factor to Rett syndrome animal model: A possible approach for the treatment of Rett syndrome

@inproceedings{Tsai2012PeripheralAO,
  title={Peripheral administration of brain-derived neurotrophic factor to Rett syndrome animal model: A possible approach for the treatment of Rett syndrome},
  author={Shih-Jen Tsai},
  booktitle={Medical science monitor : international medical journal of experimental and clinical research},
  year={2012}
}
  • Shih-Jen Tsai
  • Published 2012 in
    Medical science monitor : international medical…
Rett syndrome (RTT) is a postnatal, severe, disabling neurodevelopmental disorder occurring almost exclusively in females and is the second most common cause for genetic mental retardation in girls. In the majority of cases it is caused by mutations in gene (MECP2) encoding methyl-CpG-binding protein 2. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor playing a major role in neuronal survival, neurogenesis and plasticity. Animal studies suggested that abnormalities in BDNF… CONTINUE READING
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