Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

@article{Li2010PeripheralAA,
  title={Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.},
  author={Lei Li and J. X. Hao and Bertil B. Fredholm and Gunnar Schulte and Zsuzsanna Wiesenfeld-Hallin and X. J. Xu},
  journal={Neuroscience},
  year={2010},
  volume={170 3},
  pages={923-8}
}
Here we studied the role of peripheral adenosine A(2A) receptors in mechanical hyperalgesia during inflammation using mice lacking the A(2A) receptors. Unilateral s.c. administration of the local inflammatory agent λ-carrageenan induced profound mechanical hyperalgesia 24 h after administration in the ipsilateral hind paw in wild-type mice. In homozygous mice lacking the A(2A) receptors, carrageenan-induced hyperalgesia was significantly reduced compared to wild type controls. The reduction in… CONTINUE READING

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