Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in mice.

@article{Wang2011PeripheralAO,
  title={Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in mice.},
  author={Lixin Wang and Andreas Stengel and Miriam Goebel and V. Sanchez Martinez and G Gourcerol and Jean Rivier and Yvette F. Tach{\'e}},
  journal={Peptides},
  year={2011},
  volume={32 1},
  pages={51-9}
}
The orexigenic effect of urocortins (Ucns), namely Ucn 1, Ucn 2 and Ucn 3 through activation of corticotropin-releasing factor (CRF) receptors, has been well characterized after injection into the brain but not in the periphery. We examined the role of CRF receptor subtype 2 (CRF(2)) in the regulation of food intake using intraperitoneal (ip) injection of Ucns and the selective CRF(2) antagonist, astressin(2)-B, and CRF(2) knockout (-/-) mice. Meal structures were monitored using an automated… CONTINUE READING