Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma

@inproceedings{Postow2015PeripheralTC,
  title={Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma},
  author={Michael A Postow and Manuarii Manuel and Phillip Wong and Jianda D Yuan and Zhiwan Dong and Cailian Liu and Sol{\`e}ne Perez and Isabelle Tanneau and Marl{\`e}ne Noel and Ana{\"i}s Courtier and Nicolas Pasqual and Jedd D Wolchok},
  booktitle={Journal for immunotherapy of cancer},
  year={2015}
}
BACKGROUND Ipilimumab improves overall survival in a subset of patients with metastatic melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been associated with favorable outcomes in patients with cancer, but its relevance as a biomarker for ipilimumab outcomes remains unknown. FINDINGS In this pilot study, we analyzed the pre-treatment peripheral blood TCR repertoire in 12 patients with metastatic melanoma who received ipilimumab at 3 mg/kg (clinical benefit, n = 4; no… CONTINUE READING
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