Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice.

@article{Piqueras2004PeripheralPI,
  title={Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice.},
  author={Laura Piqueras and Yvette F. Tach{\'e} and V. Sanchez Martinez},
  journal={British journal of pharmacology},
  year={2004},
  volume={142 1},
  pages={67-78}
}
1. Studies in rats suggest that PACAP modulates gastric acid secretion through the release of both histamine and somatostatin. 2. We characterized the effects of exogenous PACAP on gastric acid secretion in urethane-anesthetized mice implanted with a gastric cannula and in conscious 2-h pylorus ligated mice, and determined the involvement of somatostatin and somatostatin receptor type 2 (SSTR2) by using somatostatin immunoneutralization, the SSTR2 antagonist, PRL-2903, and SSTR2 knockout mice… CONTINUE READING

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