Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain.


Inflammatory hyperalgesia is a complex process that depends on the sensitization of primary nociceptive neurons triggered by proinflammatory mediators, such as interleukin 1β (IL-1β). Recently, the peripheral activation of caspase-1 (previously known as IL-1β-converting enzyme) was implicated in the induction of acute inflammatory pain by promoting the… (More)
DOI: 10.1097/01.j.pain.0000460322.72396.53


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