Peripheral KV7 channels regulate visceral sensory function in mouse and human colon

@inproceedings{Peiris2017PeripheralKC,
  title={Peripheral KV7 channels regulate visceral sensory function in mouse and human colon},
  author={Madusha Peiris and James R. F. Hockley and David E. Reed and Ewan St John Smith and David C Bulmer and L Ashley Blackshaw},
  booktitle={Molecular pain},
  year={2017}
}
Background Chronic visceral pain is a defining symptom of many gastrointestinal disorders. The KV7 family (KV7.1-KV7.5) of voltage-gated potassium channels mediates the M current that regulates excitability in peripheral sensory nociceptors and central pain pathways. Here, we use a combination of immunohistochemistry, gut-nerve electrophysiological recordings in both mouse and human tissues, and single-cell qualitative real-time polymerase chain reaction of gut-projecting sensory neurons, to… CONTINUE READING
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