Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

@article{Sasso2012PeripheralFI,
  title={Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.},
  author={Oscar Sasso and Rosalia Bertorelli and Tiziano Bandiera and R. S. Scarpelli and Giampiero Colombano and Andrea Armirotti and Guillermo Moreno-Sanz and Angelo Reggiani and Daniele Piomelli},
  journal={Pharmacological research},
  year={2012},
  volume={65 5},
  pages={
          553-63
        }
}
Fatty-acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide and other bioactive lipid amides. In the present study, we conducted a comparative characterization of the effects of the newly identified brain-impermeant FAAH inhibitor, URB937 ([3-(3-carbamoylphenyl)-4-hydroxy-phenyl] N-cyclohexylcarbamate), in various rodent models of acute and persistent pain. When administered by the oral route in mice, URB937 was highly active (median effective dose… CONTINUE READING
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