Peripheral Effects of Nesfatin-1 on Glucose Homeostasis

  title={Peripheral Effects of Nesfatin-1 on Glucose Homeostasis},
  author={Ziru Li and Ling Gao and Hong Tang and Yue Yin and Xinxin Xiang and Yin Li and Jing Zhao and Michael W. Mulholland and Weizhen Zhang},
  booktitle={PloS one},
AIMS/HYPOTHESIS The actions of peripherally administered nesfatin-1 on glucose homeostasis remain controversial. The aim of this study was to characterize the mechanisms by which peripheral nesfatin-1 regulates glucose metabolism. METHODS The effects of nesfatin-1 on glucose metabolism were examined in mice by continuous infusion of the peptide via osmotic pumps. Changes in AKT phosphorylation and Glut4 were investigated by Western blotting and immnuofluorescent staining. Primary myocytes… CONTINUE READING


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