Peripheral Demyelination and Neuropathic Pain Behavior in Periaxin-Deficient Mice

@article{Gillespie2000PeripheralDA,
  title={Peripheral Demyelination and Neuropathic Pain Behavior in Periaxin-Deficient Mice},
  author={C.Stewart Gillespie and Diane L Sherman and Susan M. Fleetwood-Walker and David F. Cottrell and Steven Tait and Emer M. Garry and Victoria C. J. Wallace and Jan M. Ure and Ian Ramsey Maclachlan Griffiths and Austin Smith and Peter J Brophy},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={523-531}
}
The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex behaviors that are associated with the painful conditions caused by peripheral nerve damage. Older Prx-/- animals display extensive peripheral demyelination and a severe clinical… CONTINUE READING
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