Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential.

@article{Ungefroren2016PeripheralBM,
  title={Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential.},
  author={Hendrik Ungefroren and Ayman Hyder and Maren Schulze and Karim M Fawzy El-Sayed and Evelin Grage-Griebenow and Andreas K Nussler and Fred Faendrich},
  journal={Stem cells international},
  year={2016},
  volume={2016},
  pages={7132751}
}
Adult stem or programmable cells hold great promise in diseases in which damaged or nonfunctional cells need to be replaced. We have recently demonstrated that peripheral blood monocytes can be differentiated in vitro into cells resembling specialized cell types like hepatocytes and pancreatic beta cells. During phenotypic conversion, the monocytes downregulate monocyte/macrophage differentiation markers, being indicative of partial dedifferentiation, and are partially reprogrammed to acquire a… CONTINUE READING
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