Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.

@article{Duong2010PeripheralBC,
  title={Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.},
  author={Bao Hoa Duong and Takayuki Ota and Djemel A{\"i}t-Azzouzene and Miyo Aoki-Ota and Jos{\'e} Luis Vela and Christoph Huber and Kevin Walsh and Amanda L Gavin and David Nemazee},
  journal={Journal of immunology},
  year={2010},
  volume={184 8},
  pages={4143-58}
}
Transitional B cells turn over rapidly in vivo and are sensitive to apoptosis upon BCR ligation in vitro. However, little direct evidence addresses their tolerance sensitivity in vivo. A key marker used to distinguish these cells is IgD, which, through alternative RNA splicing of H chain transcripts, begins to be coexpressed with IgM at this stage. IgD is also expressed at high levels on naive follicular (B-2) and at lower levels on marginal zone and B-1 B cells. In this study, mice were… CONTINUE READING
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