Peripheral B-cell phenotype and BAFF levels are associated with HLA immunization in patients awaiting kidney transplantation.

@article{Snanoudj2014PeripheralBP,
  title={Peripheral B-cell phenotype and BAFF levels are associated with HLA immunization in patients awaiting kidney transplantation.},
  author={Renaud Snanoudj and Sophie Candon and Dave L Roelen and Jean-Philippe Jais and Franz H J Claas and C. Legendre and Lucienne Chatenoud},
  journal={Transplantation},
  year={2014},
  volume={97 9},
  pages={917-24}
}
BACKGROUND The role of B-cell subsets in human leukocyte antigen (HLA)-specific humoral responses in patients with end-stage renal disease is poorly documented. The objective of this study was to analyze the potential association between B-cell subsets distribution and anti-HLA antibodies before kidney transplantation. METHODS The authors studied by flow cytometry peripheral B-cell subsets and serum levels of BAFF, the main homeostatic cytokine for peripheral B cells, in 101 consecutive end… CONTINUE READING

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