Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus.

@article{Hostmann2008PeripheralBC,
  title={Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus.},
  author={Arwed Hostmann and Annett Marita Jacobi and Meirong Hao and Falk Hiepe and Thomas D{\"o}rner},
  journal={Lupus},
  year={2008},
  volume={17 12},
  pages={
          1064-9
        }
}
Autoreactive B cells and plasma cells appear to be of central importance in the pathogenesis of systemic lupus erythematosus (SLE) characterized by a plethora of autoantibodies. Recent insights into abnormalities of B cell and plasma cell compartments in human SLE have identified a number of cellular disturbances within these compartments that in part correlate with the disease activity. This review discusses these findings and the potential underlying extrinsic and/or intrinsic influences… CONTINUE READING
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