Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis

@article{Khler2017PeripheralAI,
  title={Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis},
  author={C. K{\"o}hler and T. Freitas and B. Stubbs and M. Maes and M. Solmi and N. Veronese and N. Q. de Andrade and G. Morris and Brisa Fernandes and A. Brunoni and N. Herrmann and C. Raison and B. Miller and K. Lanct{\^o}t and A. Carvalho},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={4195-4206}
}
  • C. Köhler, T. Freitas, +12 authors A. Carvalho
  • Published 2017
  • Medicine
  • Molecular Neurobiology
  • Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines and C-reactive protein. In addition, previous meta-analyses suggest that antidepressant drug treatment may decrease peripheral levels of interleukin-1 beta (IL-1β) and IL-6. Recently, several new studies examining the effect of antidepressants on these… CONTINUE READING
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