Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis

@article{Khler2017PeripheralAI,
  title={Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis},
  author={Cristiano Andr{\'e} K{\"o}hler and Thiago Holanda Freitas and Brendon Stubbs and Michael Maes and Marco Solmi and Nicola Veronese and Nayanna Q de Andrade and Gerwyn Morris and Brisa S Fernandes and Andre Russowsky Brunoni and Nathan Herrmann and Charles L. Raison and Brian J. Miller and Krista L. Lanct{\^o}t and Andr{\'e} Ferrer Carvalho},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={4195-4206}
}
Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines and C-reactive protein. In addition, previous meta-analyses suggest that antidepressant drug treatment may decrease peripheral levels of interleukin-1 beta (IL-1β) and IL-6. Recently, several new studies examining the effect of antidepressants on these… CONTINUE READING

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