Peripheral (somatic) expansion of the murine cytotoxic T lymphocyte repertoire. I. Analysis of diversity in recognition repertoire of alloreactive T cells derived from the thymus and spleen of adult or aged DBA/2J mice.

@article{Chang1984PeripheralE,
  title={Peripheral (somatic) expansion of the murine cytotoxic T lymphocyte repertoire. I. Analysis of diversity in recognition repertoire of alloreactive T cells derived from the thymus and spleen of adult or aged DBA/2J mice.},
  author={M P Chang and Reginald M Gorczynski},
  journal={Journal of immunology},
  year={1984},
  volume={133 5},
  pages={2375-80}
}
Cytotoxic T lymphocyte precursors (CTLp) in the spleen or thymus of individual adult (8 to 10 wk) or aged (greater than 20 mo) DBA/2J mice have been activated by irradiated H-2Kb antigens under limiting dilution conditions such that cytotoxic cells in responder wells result from stimulation of a single CTLp. After division into several equal samples and expansion in the presence of IL 2 and more irradiated H-2Kb stimulators, the contents of replicate individual wells were tested for their… CONTINUE READING