Periostin shows increased evolutionary plasticity in its alternatively spliced region

@inproceedings{Hoersch2009PeriostinSI,
  title={Periostin shows increased evolutionary plasticity in its alternatively spliced region},
  author={Sebastian Hoersch and Miguel A. Andrade-Navarro},
  booktitle={BMC Evolutionary Biology},
  year={2009}
}
Periostin (POSTN) is a secreted extracellular matrix protein of poorly defined function that has been related to bone and heart development as well as to cancer. In human and mouse, it is known to undergo alternative splicing in its C-terminal region, which is devoid of known protein domains. Differential expression of periostin, sometimes of specific splicing isoforms, is observed in a broad range of human cancers, including breast, pancreatic, and colon cancer. Here, we combine genomic and… CONTINUE READING

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