Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.

@article{Sehra2011PeriostinRG,
  title={Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.},
  author={Sarita Sehra and Weiguo Yao and Evelyn T. Nguyen and Ayele-Nati N. Ahyi and Florencia M. Barb{\'e} Tuana and Shawn K. Ahlfeld and Paige Snider and Robert S Tepper and Irina Petrache and Simon J. Conway and Mark H Kaplan},
  journal={Journal of immunology},
  year={2011},
  volume={186 8},
  pages={
          4959-66
        }
}
Periostin is a 90-kDa member of the fasciclin-containing family and functions as part of the extracellular matrix. Periostin is expressed in a variety of tissues and expression is increased in airway epithelial cells from asthmatic patients. Recent studies have implicated a role for periostin in allergic eosinophilic esophagitis. To further define a role for periostin in Th2-mediated inflammatory diseases such as asthma, we studied the development of allergic pulmonary inflammation in periostin… CONTINUE READING

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IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.

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  • 2017
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