Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα.

@article{Lu2014PeriostinPL,
  title={Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα.},
  author={Yan Lu and Xing Liu and Yang Jiao and Xuelian Xiong and Ena Wang and Xiao-lin Wang and Zhijian Zhang and Huijie Zhang and Lingling Pan and You-fei Guan and Dongsheng Cai and Guang Ning and Xiaoying Li},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 8},
  pages={3501-13}
}
Hepatosteatosis is characterized by an aberrant accumulation of triglycerides in the liver; however, the factors that drive obesity-induced fatty liver remain largely unknown. Here, we demonstrated that the secreted cell adhesion protein periostin is markedly upregulated in livers of obese rodents and humans. Notably, overexpression of periostin in the livers of WT mice promoted hepatic steatosis and hypertriglyceridemia. Conversely, both genetic ablation of periostin and administration of a… CONTINUE READING