Periostin is required for maximal airways inflammation and hyperresponsiveness in mice.

@article{Bentley2014PeriostinIR,
  title={Periostin is required for maximal airways inflammation and hyperresponsiveness in mice.},
  author={J Kelley Bentley and Qiang Chen and Jun Young Hong and Antonia P. Popova and Jing Lei and Bethany B Moore and Marc B Hershenson},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={134 6},
  pages={1433-1442}
}
BACKGROUND Periostin, a secreted extracellular matrix protein, has been localized to deposits of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13. OBJECTIVE We hypothesized that periostin is required for airway inflammatory responses to a physiologic aeroallergen, house dust mite (HDM). METHODS We studied F4-F6 B6;129-Postn(tm1Jmol)/J wild-type (Postn(+/+)) and null (Postn(-/-)) mice, as well as C57BL/6 mice treated with either IgM or… CONTINUE READING
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