Periostin is essential for cardiac healingafter acute myocardial infarction

  title={Periostin is essential for cardiac healingafter acute myocardial infarction},
  author={Masashi Shimazaki and Kazuto Nakamura and Isao Kii and Takeshi G Kashima and Norio Amizuka and Minqi Li and Mitsuru Saito and Keiichi Fukuda and Takashi Nishiyama and Satoshi Kitajima and Yumiko Saga and Masashi Fukayama and Masataka Sata and Akira Kudo},
  journal={The Journal of Experimental Medicine},
  pages={295 - 303}
Acute myocardial infarction (AMI) is a common and lethal heart disease, and the recruitment of fibroblastic cells to the infarct region is essential for the cardiac healing process. Although stiffness of the extracellular matrix in the infarct myocardium is associated with cardiac healing, the molecular mechanism of cardiac healing is not fully understood. We show that periostin, which is a matricellular protein, is important for the cardiac healing process after AMI. The expression of… CONTINUE READING
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