Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma.

@article{Sung2016PeriostinIT,
  title={Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma.},
  author={P L Sung and Y W Jan and Shih-Chieh Lin and Chao-Cheng Huang and Hao Lin and Kuo-Chang Wen and K C Chao and C L Lai and Peng-Hui Wang and Chi-Mu Chuang and Hua-Hsi Wu and N F Twu and Ming Shyen Yen and Michael Hsiao and Chi-Ying F Huang},
  journal={Oncotarget},
  year={2016},
  volume={7 4},
  pages={4036-47}
}
The interplay between tumor microenvironment and cancer that causes chemoresistance remains unclear. By analyzing public available microarray datasets, we identified that periostin (POSTN) was overexpressed in cancer stroma in epithelial ovarian cancer (EOC) patients. Immunohistochemistry analysis showed overexpression of stromal POSTN is a powerful independent poor prognostic predictor for EOC patients. Furthermore, patients with high levels of stromal POSTN tend to have higher percentage of… CONTINUE READING
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