Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension


Periostin is an extracellular matrix protein involved in fibrosis. The present study investigated the importance of periostin in hypertension‑induced myocardial fibrosis. Rats were randomly divided into either the normal group (0.4% NaCl diet; n=8) or hypertension group (8% NaCl diet; n=8). For 36 weeks, the blood pressure and heart rate of the rats were… (More)
DOI: 10.3892/mmr.2016.5308


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