Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton.

Abstract

The epicardium is embryologically formed by outgrowth of proepicardial cells over the naked heart tube. Epicardium-derived cells (EPDCs) migrate into the myocardium, contributing to myocardial architecture, valve development, and the coronary vasculature. Defective EPDC formation causes valve malformations, myocardial thinning, and coronary defects. In the… (More)
DOI: 10.1111/j.1432-0436.2007.00262.x

Topics

Cite this paper

@article{LieVenema2008PeriostinEB, title={Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton.}, author={Heleen Lie-Venema and I Levent Eralp and Roger R. Markwald and Nynke M. S. van den Akker and Maurits C. E. F. Wijffels and Denise P. Kolditz and Arnoud van der Laarse and Martin Jan Schalij and Robert E. Poelmann and Ad J. J. C. Bogers and Adriana C. Gittenberger-de Groot}, journal={Differentiation; research in biological diversity}, year={2008}, volume={76 7}, pages={809-19} }