Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions.

@article{Kashima2009PeriostinAN,
  title={Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions.},
  author={Takeshi G Kashima and Takashi Nishiyama and Kazuhiro Shimazu and Masashi Shimazaki and Isao Kii and Agamemnon E. Grigoriadis and Masashi Fukayama and Akira Kudo},
  journal={Human pathology},
  year={2009},
  volume={40 2},
  pages={226-37}
}
Fibrous dysplasia is a benign bone disease caused by a mutation in the gene for the stimulatory guanine nucleotide-binding protein Gs alpha, leading to high cyclic adenosine monophosphate levels. Histologically, fibrous dysplasia is characterized by the production of fibrous tissue accompanied by the deposition of ectopic type I collagen and other bone-associated extracellular matrix proteins, as well as by irregular woven intramembranous bone onto which type I collagen-containing Sharpey… CONTINUE READING

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