Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.

@article{Coutu2008PeriostinAM,
  title={Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.},
  author={Daniel L Coutu and Jian Hui Wu and Anne Monette and G B Rivard and Mark D. Blostein and Jacques Galipeau},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 26},
  pages={17991-8001}
}
The modification of glutamic acid residues to gamma-carboxyglutamic acid (Gla) is a post-translational modification catalyzed by the vitamin K-dependent enzyme gamma-glutamylcarboxylase. Despite ubiquitous expression of the gamma-carboxylation machinery in mammalian tissues, only 12 Gla-containing proteins have so far been identified in humans. Because bone tissue is the second most abundant source of Gla-containing proteins after the liver, we sought to identify Gla proteins secreted by bone… CONTINUE READING
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