Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trial.

@article{Lanc2012PerioperativeDC,
  title={Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trial.},
  author={Marcus D Lanc{\'e} and Marisa Ninivaggi and Saskia E. M. Schols and Marion A. H. Feijge and Stephanie Oehrl and Gerhardus J A J M Kuiper and Maria Nikiforou and Marco A. E. Marcus and Karly Hamul{\'y}ak and Elisabeth C M van Pampus and Hugo Ten Cate and Johan W. M. Heemskerk},
  journal={Vox sanguinis},
  year={2012},
  volume={103 1},
  pages={25-34}
}
BACKGROUND AND OBJECTIVES   Treatment of dilutional coagulopathy by transfusing fresh frozen plasma (FFP) remains sub-optimal. We hypothesized that partial replacement of transfused FFP by fibrinogen concentrate results in improved coagulant activity and haemostasis. This was tested in a controlled clinical intervention trial with patients experiencing massive bleeding during major surgery. METHODS   Patients undergoing major elective surgery were treated according to current protocols. When… CONTINUE READING
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