Perioperative chemotherapy with and without high-dose methotrexate in adult osteosarcoma.

Abstract

Treatment of adult osteosarcoma (AOS) includes perioperative chemotherapy and surgery. Standard chemotherapy consists of cisplatin (CP) and doxorubicin (DOX). Although considered the standard of care for pediatric patients, high-dose methotrexate (HDM) remains controversial in adults. We aimed to evaluate the role of HDM in AOS treated with curative intent… (More)
DOI: 10.1097/CAD.0000000000000533

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@article{Negro2017PerioperativeCW, title={Perioperative chemotherapy with and without high-dose methotrexate in adult osteosarcoma.}, author={Marcelo Vailati Negr{\~a}o and Lucila Soares da Silva Rocha and Daniel da Motta Girardi and Olavo Feher}, journal={Anti-cancer drugs}, year={2017}, volume={28 8}, pages={915-921} }