MOJ Womens Health 2017, 5(4): 00129 Perioperative prophylaxis with Danazol and C1 inhibitor concentrate (C1-INH) are commonly used to prevent angioedema episodes. Anaesthesia management and perioperative implications have been recently commented by some authors . Airway oedema and hypovolemic shock due to the tissue leak of fluids are especially significant in the perioperative period, challenging even the most experienced anaesthesiologist. We represent a patient who had previously diagnosed HEA who underwent successful elective Novasure endometrial ablation under general anaesthetic. Perioperative management and anaesthetic implications are discussed below in details.