Perioperative Fluid Management Strategies in Major Surgery: A Stratified Meta-Analysis

  title={Perioperative Fluid Management Strategies in Major Surgery: A Stratified Meta-Analysis},
  author={Tom{\'a}s B Corcoran and Julia Emma Joy Rhodes and S. Clarke and Paul S. Myles and Kwok M. Ho},
  journal={Anesthesia \& Analgesia},
BACKGROUND: Both “liberal” and “goal-directed” (GD) therapy use a large amount of perioperative fluid, but they appear to have very different effects on perioperative outcomes. We sought to determine whether one fluid management strategy was superior to the others. METHODS: We selected randomized controlled trials (RCTs) on the use of GD or restrictive versus liberal fluid therapy (LVR) in major adult surgery from MEDLINE, EMBASE, PubMed (1951 to April 2011), and Cochrane controlled trials… 

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