Periodontal therapy: a novel acute inflammatory model

  title={Periodontal therapy: a novel acute inflammatory model},
  author={Francesco D’Aiuto and Mohamed H. Parkar and Maurizio S Tonetti},
  journal={Inflammation Research},
Objective and Design: We designed a clinical trial at the Eastman Dental Hospital with the objective of developing a novel in vivo inflammatory model. Subjects: We recruited 55 subjects suffering from severe periodontitis. Treatment: Participants received intensive periodontal therapy. Methods: Blood samples were collected at baseline and 1 and 7 and 30 days after treatment and processed for a series of biomarkers (TNF-alpha, IL-6, CRP and Fibrinogen) by high-sensitivity assays and differential… CONTINUE READING

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