Periodic vs constant high glucose in inducing pro-inflammatory cytokine expression in human coronary artery endothelial cells

@article{Liu2013PeriodicVC,
  title={Periodic vs constant high glucose in inducing pro-inflammatory cytokine expression in human coronary artery endothelial cells},
  author={Tingsong Liu and Jianbin Gong and Yitian Chen and Shisen Jiang},
  journal={Inflammation Research},
  year={2013},
  volume={62},
  pages={697-701}
}
Fluctuating hyperglycemia exerts a more deleterious effect than constant hyperglycemia on cardiovascular outcome in diabetic patients. We investigated the inflammatory responses of human coronary artery endothelial cells (HCAECs) to constant and periodic high glucose in vitro. HCAECs were incubated for 72 h continuously either in normal glucose (5.5 mmol/L), constant high glucose (25 mmol/L glucose), periodic high glucose (5.5 and 25 mmol/L glucose alternating every 6 h) or mannitol… CONTINUE READING

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