Periodic paralysis and the sodium-potassium pump.

  title={Periodic paralysis and the sodium-potassium pump.},
  author={Robert B. Layzer},
  journal={Annals of neurology},
  volume={11 6},
Analysis of the pathophysiology of hypokalemic paralysis, as it occurs in barium poisoning, chronic potassium deficiency, and thyrotoxicosis, suggests that these disorders may have a similar mechanism. An increased ratio of muscle sodium permeability to potassium permeability reduces the ionic diffusion potential, while the resting membrane potential is sustained by an increase of Na-K pump electrogenesis. The result is that potassium entry (the sum of active and passive influx) exceeds… CONTINUE READING