Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood.

@article{Lajud2012PeriodicMS,
  title={Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood.},
  author={Naima Lajud and Ang{\'e}lica Roque and Marco Cajero and Gabriel Guti{\'e}rrez-Ospina and Luz M. Torner},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37 3},
  pages={410-20}
}
Although not directly evaluated, the early rise of glucocorticoid (GC) levels, as occur after exposure to adverse early life experience, are assumed to affect hippocampal ontogeny by altering the hippocampus negative feedback on adult HPA axis. To test whether hippocampal ontogeny is affected by early exposure to stress we estimated the survival of recently formed hippocampal granule cells in rat pups subjected to periodic maternal separation (180 min/day; MS180) from postnatal days (PND) 1 to… CONTINUE READING
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