Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production.

@article{Kolly2013PeriodicFA,
  title={Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production.},
  author={Laeticia Kolly and Nathalie Busso and Annette von Scheven-G{\^e}te and Nathaliane Bagnoud and Isabelle Moix and Dirk Holzinger and Gregoire Simon and Annette Ives and Greta Guarda and Alexander So and M A Morris and Micha{\"e}l F. Hofer},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={131 6},
  pages={1635-43}
}
BACKGROUND The exact pathogenesis of the pediatric disorder periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is unknown. OBJECTIVES We hypothesized that PFAPA might be due to dysregulated monocyte IL-1β production linked to genetic variants in proinflammatory genes. METHODS Fifteen patients with PFAPA syndrome were studied during and outside a febrile episode. Hematologic profile, inflammatory markers, and cytokine levels were measured in the blood. The… CONTINUE READING
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