Periodic Cyclin-Cdk Activity Entrains an Autonomous Cdc14 Release Oscillator

@article{Lu2010PeriodicCA,
  title={Periodic Cyclin-Cdk Activity Entrains an Autonomous Cdc14 Release Oscillator},
  author={Ying Lu and Frederick R Cross},
  journal={Cell},
  year={2010},
  volume={141},
  pages={268-279}
}
One oscillation of Cyclin-dependent kinase (Cdk) activity, largely driven by periodic synthesis and destruction of cyclins, is tightly coupled to a single complete eukaryotic cell division cycle. Tight linkage of different steps in diverse cell-cycle processes to Cdk activity has been proposed to explain this coupling. Here, we demonstrate an intrinsically oscillatory module controlling nucleolar release and resequestration of the Cdc14 phosphatase, which is essential for mitotic exit in… CONTINUE READING
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