Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK.

@article{Rawashdeh2016Period1GT,
  title={Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK.},
  author={Oliver Rawashdeh and Antje Jilg and Erik Maronde and Jan Fahrenkrug and J{\"o}rg H. Stehle},
  journal={Journal of neurochemistry},
  year={2016},
  volume={138 5},
  pages={731-45}
}
Memory performance varies over a 24-h day/night cycle. While the detailed underlying mechanisms are yet unknown, recent evidence suggests that in the mouse hippocampus, rhythmic phosphorylation of mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate response element-binding protein (CREB) are central to the circadian (~ 24 h) regulation of learning and memory. We recently identified the clock protein PERIOD1 (PER1) as a vehicle that translates information encoding time of… CONTINUE READING
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