Period shift induction by intermittent stimulation in a Drosophila model of PER protein oscillations.

@article{Claude2000PeriodSI,
  title={Period shift induction by intermittent stimulation in a Drosophila model of PER protein oscillations.},
  author={Daniel Claude and Jean Clairambault},
  journal={Chronobiology international},
  year={2000},
  volume={17 1},
  pages={1-14}
}
PER protein circadian oscillations in Drosophila have been described by Goldbeter according to a five-dimensional model that includes the possibility of genetic mutation described by changing one parameter, the maximum degradation rate of the PER protein. Assuming that, in a mutant Drosophila this parameter is unreachable, we modify another parameter, the translation rate between the mRNA and the nonphosphorylated form of PER protein, by periodic intermittent activation or inhibition. We show… CONTINUE READING