Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularization

@article{Gehlbach2003PeriocularIO,
  title={Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularization},
  author={Peter Gehlbach and Anna Maria Demetriades and Seiji Yamamoto and Tye G. Deering and Elia J. Duh and Hoseong S Yang and Celia Cingolani and Hong Ji Lai and Lisa Wei and Peter Anthony Campochiaro},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={637-646}
}
Gene transfer provides an exciting new approach for the treatment of retinal and choroidal diseases. Two areas of concern are the potential for vector-related toxicity and uncertainties associated with prolonged transgene expression. One way to address these concerns for transfer of genes encoding secreted proteins is to transduce cells on the outside of the eye, provided the gene product can gain access to the eye and have the desired effect. In this study, we investigated the feasibility of… CONTINUE READING
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